Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversionArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addition antibodies Antibody Response approach AUC collected COVID-19 COVID-19 patient diagnostic diagnostics Donor Extreme early-stage seroconversion faster flow cytometry healthy IgG IgG and IgM IgG/IgM antibodies IgM immunoassay immunoassays immunological inactivated nucleic acid nucleic acids other diseases pathogen-specific Patient peptide platform probe Protein RBD reveal Rhesus monkeys SARS-CoV-2 S2 sensitivity Seroconversion seroconversion time Simoa tested Ultrasensitive digital detection. vaccination virus wild-type [DOI] 10.1016/j.bios.2022.114710 PMC 바로가기
Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Association of Results of Four Lateral Flow Antibody Tests with Subsequent SARS-CoV-2 InfectionArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome adjusted anti-SARS-CoV-2 IgG antibody assist association baseline Cohort cohort study conducted coronavirus Coverage COVID COVID-19 demonstrated disease risk England fire Flow Follow-up hospital IgG Immunity immunoassay immunoassays incidence rate individual Infection investigated Laboratory laboratory assays Lateral Lateral flow device lateral flow device. lateral flow immunoassay Lateral flow test LFIA LFIAs management microbiologically natural infection pandemic participant point-of-care test Poisson regression model Police service Population screening positive predicted prospective cohort study Protective Rapid Rapid test rapid test cassette recruitment Research Result risk risk factor Roche SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 IgG SARS-COV-2 infection specificity subsequent Surescreen susceptibility symptomatic SARS-CoV-2 infection Test threshold United Kingdom unvaccinated populations Vaccine was tested [DOI] 10.1128/spectrum.02468-22 PMC 바로가기
Concordance of SARS-CoV-2 Antibody Results during a Period of Low PrevalenceArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval Abbott acute respiratory syndrome Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Antigen antigens Architect assays CDC collected combinations Concentration Concordance contributed coronavirus coronavirus disease COVID-19 Elecsy ELISA enzyme-linked immunosorbent evaluate False positivity first test Frequency IgG IgG antibodies immunoassay immunoassays Immunoglobulin individual investigated low prevalence nucleocapsid nucleocapsid protein pandemic participant Participants performed Period positive positive result Prevalence produced proportion quantified Research Result Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sequential test sera serological test seropositive specimen Spike protein spike protein. subset Support target tested the SARS-CoV-2 The United States Vaccine vaccine availability [DOI] 10.1128/msphere.00257-22 PMC 바로가기
Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Affect analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody antibody assay Antibody assays antigenic antigenic structure antigens assays change changes in characterized controls convalescent individual correlation diagnostic immunoassay immunoassays immunoreactivity impairing individual Infection lack neutralization Neutralization assay Neutralizing activity Neutralizing antibodies Neutralizing antibody titer omicron Primary infection Protein quantified RBD reduced SARS-CoV-2 SARS-CoV-2-specific antibody sensitivity significantly spike statistically significant reduction subjects surrogate assay. tested the SARS-CoV-2 the Spike variant variants were used wild type wild-type wild-type strain [DOI] 10.1128/spectrum.02129-22 PMC 바로가기
Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patientsArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 binding addition administration analysed anti-RBD B.1 binding BNT162b2 boost immunity cellular Control controls COVID-19 COVID-19 vaccination Decline declining Delta detectable dialysis dose doses group Haemodialysis Haemodialysis patient humoral humoral immune response Humoral immunity IgG IgG response immune immune evasion immune protection immunoassays Immunocompromised individual individuals information interferon γ knowledge longitudinal longitudinal response maintain mixed mRNA vaccination mRNA mRNA vaccination mRNA-1273 mucosal omicron Omicron variant of concern Patient patients Prevent protective immunity protective immunity. RBD reached regimen remained respond poorly restored SARS-CoV-2 vaccination SARS-CoV-2 variant second vaccination severe COVID-19 significantly increased spike subsequent Support T-cell Response tested the receptor-binding domain vaccination Vaccine variant variants of concern [DOI] 10.3389/fimmu.2022.1004045 PMC 바로가기
Evaluating the role of a fully automated SARS-CoV-2 antigen ECLIA immunoassay in the management of the SARS COV 2 pandemic on general populationArticle Published on 2022-10-032023-07-10 Journal: Diagnosis (Berlin, Germany) [Category] COVID19(2023년), [키워드] fourth-generation antigen test immunoassays SARS-CoV-2 Viral load. [DOI] 10.1515/dx-2022-0067 PMC 바로가기
Automated measurement of coagulation and fibrinolytic activation markers: Outcomes in coronavirus disease 2019 (COVID-19) patientsArticle Published on 2022-10-012022-11-15 Journal: International journal of laboratory hematology [Category] 바이오마커, [키워드] 95% CI accompanied Activation addition Admission automated Blood coagulation characterized chemiluminescent assays Coagulation collected complex coronavirus disease COVID-19 D-dimer Disease progression endothelial damage Endothelial dysfunction enzyme fibrinolysis fibrinolytic Haematology hospital hypoxaemia immunoassays independent independent risk factor inhibitor Logistic regression lung Mortality non-survivor Odds ratio oedema parameter Patient patients hospitalized performed retrospective significantly Survivors TAT thrombomodulin tissue variable Vascular endothelium Vascular endothelium. was performed with COVID-19 [DOI] 10.1111/ijlh.13855 PMC 바로가기
A comprehensive review of COVID-19 detection techniques: From laboratory systems to wearable devicesReview article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Asymptomatic Asymptomatic COVID-19 asymptomatic individual asymptomatic patient asymptomatic patients blood pressure body temperature cardiovascular condition changes in coronavirus COVID-19 COVID-19 infection diagnostic Diseases domain effort Healthcare system identify immunoassays individual infected individual isothermal amplification Laboratory machine learning monitoring system novel coronavirus disease offer parameters Patient physiological resources respiratory infection reverse transcription robust RT-LAMP RT-PCR SARS-CoV-2 Screening shown spread of COVID-19 symptomatic and asymptomatic Symptomatic patients Transmission unique Vital Wearable systems [DOI] 10.1016/j.compbiomed.2022.106070 [Article Type] Review article